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Purpose To detect the prevention of EGF and GLN on the side effect of TPN. Methods We randomized SD rats into four groups:group A (control),B(STPN),C(TPN+GLN),D(TPN+GLN+EGF).All rats were maintained on their respective diets for 8 days,at which time they were killed and the proximal jejunum was incised for biopsy,the MLN and celiac vein blood were collected for bacterial culture(aerobic culture). Results Group B rat mucosal cell atrophied,DNA and RNA content and plasma cell decreased,the positive rat of MLN bacterial culture was 62.5%.Atrophy in group C alleviated and bacterial translocation rate declined(37.5%).Group D was similar with group A. Conclusions GLN combined with EGF is more effective in protecting gut barrier function and preventing bacterial translocation than GLN alone.
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Objective:To inquire into the prophylaxis and treatment of fungal infection following abdominal surgery.Methods: Retrospectively analyzed the diagnoses,the inducing factors, the treatments and the progreoses of 136 cases fungal infections complicated by abdominal sugery from 1990 to 1999 June. Results : Analyzed and explained that the fungal kinds and invasions relate to the abuse of artibiotic, oldness and weakness, the use of immunosuppression and the low immunity function. Couclusion : We should raise the cognition of the fungal infection following abdominal surgery and achieve early diagnosis and prompt treatment in order to avoid the serious consequences of fungal septicemia and multiple organ dysfunction syndrome.
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Objective To introduce the current status of the diagnosis and treatment of acute pancreatitis (AP). Methods With the reference of relevent articles issued in this periodical, the summary was mad on author's professinal knowledge and special clinical experience. Results and conclusions The pathology of AP is varied. The staging of AP is divided into mild type and severe type. 90% of patients with AP take a mild course and clinical improvement can be achieved by non operative therapy; meanwhile the other 10% of patients of AP take a severity course and operation is necessary when the patients complicated with infection. Operation principle: the timing is not to be early and the procedure is not to be large. New advance had been made in the diagnosis and treatment of AP, which has improved the curative rate and reduced the mortality. For some causes, nation standard of diagnosis and treatment of AP could not been performed in many primary hospitals. It is effective for primary hospital to treat AP with Chinese medicine. The author provides four items in experience: early diagnosis, distinguishing the staging of AP(mild or severe) and improving curative effect; reducing course of treatment; preventing complicantions; and combining Chinese medicine with west medicine for AP. This is the current status of diagnosis and treatment of AP in China.
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Objective To study the damaging effect of tumor necrosis factor-alpha (TNF-?) and Interleukin-1?(IL-1?) on brain of rats in acute pancreatitis(AP). Mothods AP pancreatitis model in rats was induced by retrograde injection of 5% sodium taurocholate into the pancreatobiliary duct(1ml/kg body weight), then pretreated with normal saline (NS) or TNF-??IL-1?, TNF-? plus IL-1? respectively. Animals were killed at 5 h after drugs administration. The changes of brain water contents, leukocyte accumulation and adhesion were measured, and pathological studies of pancreas and brain were also performed. Results In groups with inflammatory cytokines pretreated, brain water contents, leukocyte accumulation and adhesion increased more significantly than those in control group and in NS pretreated group(P0.05). Conclusions Inflammatory cytokines such as TNF-? and IL-1? play important roles in the formation and acceleration of the brain damage in acute pancreatitis.